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Frozen shoulder syndrome, also known as adhesive capsulitis, is a debilitating condition characterized by pain and stiffness in the shoulder joint, leading to limited range of motion. Despite its high prevalence and impact on individuals, the molecular biology underlying limited shoulder motion in frozen shoulder syndrome remains poorly understood. This paper aims to provide an overview of the current knowledge regarding the molecular mechanisms involved in the pathogenesis of frozen shoulder syndrome. This paper also discusses the diagnostic and therapeutic implications of understanding the molecular biology of limited shoulder motion in frozen shoulder syndrome. Molecular markers for early diagnosis and prognosis could aid in identifying individuals at risk and guide treatment strategies. Targeted therapies based on the molecular mechanisms involved in frozen shoulder syndrome, including gene therapy and regenerative medicine approaches, show promise for future interventions. Despite recent advancements, several questions remain unanswered, and challenges persist in studying the molecular biology of frozen shoulder syndrome. Further research, interdisciplinary collaborations, and translational studies are needed to unravel the complexities of this condition and improve patient outcomes. Continued investigation into the molecular basis of limited shoulder motion in frozen shoulder syndrome holds significant potential for advancing our understanding and developing effective treatments for this debilitating condition.
 Jump C M, Duke K, Malik R A, et al. Frozen shoulder: a systematic review of cellular, molecular, and metabolic findings [J]. JBJS reviews, 2021, 9(1): e19.
 De la Serna D, Navarro-Ledesma S, Alayón F, et al. A comprehensive view of frozen shoulder: a mystery syndrome [J]. Frontiers in Medicine, 2021, 8: 638.
 Millar N L, Meakins A, Struyf F, et al. Frozen shoulder [J]. Nature Reviews Disease Primers, 2022, 8(1): 59.
 Andronic O, Ernstbrunner L, Jüngel A, et al. Biomarkers associated with idiopathic frozen shoulder: a systematic review [J]. Connective tissue research, 2020, 61(6): 509-516.
 Mertens M G, Meeus M, Verborgt O, et al. An overview of effective and potential new conservative interventions in patients with frozen shoulder [J]. Rheumatology International, 2022, 42(6): 925-936.
 Pandey V, Madi S. Clinical guidelines in the management of frozen shoulder: an update! [J]. Indian journal of orthopaedics, 2021, 55(2): 299-309.
 Qin X, Sun K, Ao Y, et al. Traditional Chinese medicine for frozen shoulder: An evidence-based guideline [J]. Journal of Evidence-Based Medicine, 2023.
 Kamal N, McGee S L, Eng K, et al. Transcriptomic analysis of adhesive capsulitis of the shoulder [J]. Journal of Orthopaedic Research®, 2020, 38(10): 2280-2289.
 Karnawat S, Harikesavan K, Venkatesan P. Effect of Functional Scapular Stabilization Training on Function and Pain in Frozen Shoulder Syndrome: A Randomized Controlled Trial [J]. Journal of Manipulative and Physiological Therapeutics, 2023, 46(2): 86-97.
 Kamatagi M, Jadhav L L. Clinical study on the effectiveness of Vatagajankusha Rasa with Pippali Churna and Manjishta Kwatha as Anupana in Apabahuka (Frozen Shoulder) [J]. Journal of Ayurveda and Integrated Medical Sciences, 2022, 7(11): 01-07.