Sign in Register Submit Manuscript

Damray Home

Location: Home >> Development Status and Application of Tricalcium Phosphate in Oral Clinical Treatment

  • donwnload article

    Download Article

  • donwnload article

    Share Article

Article

Development Status and Application of Tricalcium Phosphate in Oral Clinical Treatment

Zhizhao Hu, Tingrui Ge, Shihan Wu, Yang Hu*, Xingxing Ma

Xinjiang Medical University, 830000, Urumqi City, Xinjiang Uygur Autonomous Region, China.

*Corresponding author: Yang Hu

Published: November 18,2022 How to cite this paper

Abstract

Tricalcium phosphate (TCP) substitutes have been used as synthetic bone gap fillers in dental and orthopaedic applications because of their biocompatibility and high mechanical stiffness. Tricalcium phosphate (TCP) can be divided into low temperature phase β-TCP and high temperature phase α-TCP, among which β-TCP is one of the best materials to meet the requirements of bone tissue engineering scaffold. During bone regeneration, β-TCP exhibits absorbable characteristics and is completely replaced by new bone tissue after stimulating bone formation. Pure β-TCP is a fragile white solid whose color may change due to the presence of impurities. β-TCP is one of the most attractive alternatives to bone graft due to its synthetic properties, bone conduction, bone induction, and cell-mediated reabsorption. It has been proposed as a vehicle for topical applica-tion of drugs (bone morphogenetic proteins, antibiotics) to defect sites and has been widely used in dental and orthopedic bone regeneration applications. In this paper, the application of β-TCP in oral clinic and the new research progress at home and abroad are reviewed, providing a theoretical basis for the future application of β-TCP in oral routine diagnosis and treatment.

KEYWORDS: Tricalcium phosphate, Oral clinical, Development status and application

References

[1] Guerrero-Girones, J.; Alcaina-Lorente, A.; Ortiz-Ruiz, C.; Ortiz-Ruiz, E.; Pecci-Lloret, M. P.; Ortiz-Ruiz, A. J.; Rodri-guez-Lozano, F. J.; Pecci-Lloret, M. R., Biocompatibility of a HA/beta-TCP/C Scaffold as a Pulp-Capping Agent for Vital Pulp Treatment: An In Vivo Study in Rat Molars. Int J Environ Res Public Health, 2021, 18(8).

[2] Baheiraei, N.; Nourani, M. R.; Mortazavi, S. M. J.; Movahedin, M.; Eyni, H.; Bagheri, F.; Norahan, M. H. Development of a bioactive porous collagen/beta-tricalcium phosphate bone graft assisting rapid vascularization for bone tissue engineering applications. J Biomed Mater Res A, 2018, 106 (1), 73-85.

[3] Bettach, R.; Guillaume, B.; Taschieri, S.; Del Fabbro, M. Clinical performance of a highly porous beta-TCP as the grafting material for maxillary sinus augmentation. Implant Dent, 2014, 23 (3), 357-64.

[4] Castro, V. O.; Fredel, M. C.; Aragones, Á.; de Oliveira Barra, G. M.; Cesca, K.; Merlini, C. Electrospun fibrous membranes of poly (lactic-co-glycolic acid) with β-tricalcium phosphate for guided bone regeneration application. Polymer Testing, 2020, 86.

[5] Hu, S.; Li, C. M.; Zhang, S. Y.; Qin, S.; Xie, C. L.; Niu, Z. X.; Sun, M. L. [Clinical value of oral repair membrane and beta-tricalcium phosphate in the treatment of the postoperative bone defect of jaw cyst]. Hua Xi Kou Qiang Yi Xue Za Zhi 2020, 38 (5), 541-545.

[6] Lin, H. K.; Pan, Y. H.; Salamanca, E.; Lin, Y. T.; Chang, W. J. Prevention of Bone Resorption by HA/beta-TCP + Collagen Composite after Tooth Extraction: A Case Series. Int J Environ Res Public Health, 2019, 16 (23).

[7] Mendes de Almeida, C.; Ribeiro, J. S.; Welter Meereis, C. T.; Ogliari, A. O.; da Silveira Noremberg, B.; Ogliari, F. A.; Michelon, D.; Lund, R. G. β-TCP nanoparticles doped with antimicrobial agents as an orthodontic adhesive component. International Journal of Adhesion and Adhesives, 2021, 110.

[8] Putri, T. S.; Hayashi, K.; Ishikawa, K. Bone regeneration using beta-tricalcium phosphate (beta-TCP) block with interconnected pores made by setting reaction of beta-TCP granules. J Biomed Mater Res A, 2020, 108 (3), 625-632.

[9] Viale-Bouroncle, S.; Bey, B.; Reichert, T. E.; Schmalz, G.; Morsczeck, C. beta-tricalcium-phosphate stimulates the differentiation of dental follicle cells. J Mater Sci Mater Med., 2011, 22 (7), 1719-24.

[10] Yu, S.; Shi, J.; Liu, Y.; Si, J.; Yuan, Y.; Liu, C. A mechanically robust and flexible PEGylated poly(glycerol sebacate)/ β-TCP nanoparticle composite membrane for guided bone regeneration. Journal of Materials Chemistry B, 2019, 7 (20), 3279-3290.

[11] Fatale Valentina, Pagnoni Stefano, Pagnoni Albino Emidio, Passarelli Pier Carmine, Netti Andrea, Lajolo Carlo, Santacroce Luigi, D’Addona Antonio. Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal Stem Cells and Beta-Tricalcium Phosphate: A Controlled Clinical Trial [J]. Journal of Craniofacial Surgery, 2022, 33(5).

[12] Gupta Amit, Arora Karandeep, Aggarwal Priyanka, Kaur Kirandeep, Mohapatra Shreeyam, Pareek Shubhangi. Evaluation of biphasic hydroxapatite and β-tricalcium phosphate as a bone graft material in the treatment of periodontal vertical bony defects—A clinical and digital radiological measurement study [J]. Indian Journal of Dental Research, 2022, 33(2).

[13] Zhang Xin, Wang Chenglin, Yang Jing, Ye Ling. Epigenetic regulation of dental pulp stem cells [J]. International Journal of Stomatology, 2018, 45(03):261-266.

[14] Mendes Bruno Coelho, Pereira Rodrigo dos Santos, Mourão Carlos Fernando de Almeida Barros, Montemezzi Pietro, Santos Anderson Maikon de Souza, Moreno Jéssica Monique Lopes, Okamoto Roberta, HochuliVieira Eduardo. Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial [J]. Materials, 2022, 15(5).

[15] Jeong WooShik, Kim Young Chul, Min Jae Cheong, Park HoJin, Lee EunJu, Shim JinHyung, Choi JongWoo. Clinical Application of 3D-Printed Patient-Specific Polycaprolactone/Beta Tricalcium Phosphate Scaffold for Complex Zygomatico-Maxillary Defects [J]. Polymers, 2022, 14(4).

[16] RocaMillan Elisabet, JanéSalas Enric, MaríRoig Antonio, JiménezGuerra Álvaro, OrtizGarcía Iván, VelascoOrtega Eugenio, LópezLópez José, MonsalveGuil Loreto. The Application of Beta-Tricalcium Phosphate in Implant Dentistry: A Systematic Evaluation of Clinical Studies [J]. Materials, 2022, 15(2).

[17] Asahina Izumi, Kagami Hideaki, Agata Hideki, Honda Masaki J., Sumita Yoshinori, Inoue Minoru, NagamuraInoue Tokiko, Tojo Arinobu. Clinical Outcome and 8-Year Follow-Up of Alveolar Bone Tissue Engineering for Severely Atrophic Alveolar Bone Using Autologous Bone Marrow Stromal Cells with Platelet-Rich Plasma and β-Tricalcium Phosphate Granules [J]. Journal of Clinical Medicine, 2021, 10(22).

[18] Liang Dawei, Pei Jia, Zhang Leilei, Ling Haonan, Liu Youwen, Chen Xiantao. Treatment of pre-collapse non-traumatic osteo-necrosis of the femoral head through Orthopdische Chirurgie München approach combined with autologous bone mixed with β-tricalcium phosphate porous bioceramic bone graft: a retrospective study of mid-term results [J]. Journal of Orthopaedic Surgery and Research, 2021, 16(1).

[19] Jasser Reham AL, AlSubaie Abdulelah, AlShehri Fayez. Effectiveness of beta-tricalcium phosphate in comparison with other materials in treating periodontal infra-bony defects around natural teeth: a systematic review and meta-analysis [J]. BMC Oral Health, 2021, 21(1).

[20] Pavani Mudambi, Reddy Konda, Reddy Bavigadda, Biraggari Sunil, Babu C, Chavan Vinay. Evaluation of platelet-rich fibrin and tricalcium phosphate bone graft in bone fill of intrabony defects using cone-beam computed tomography: A randomized clinical trial [J]. Journal of Indian Society of Periodontology, 2021, 25(2).

[21] Preethi K., Kumar V. Gireesh, Raghavender K.B.P., Kumar D. Pramod, Lakshman M. Use of beta-tricalcium phosphate bone graft with collagen membrane as guided bone regeneration in long bone fractures with bone loss in dogs: A clinical study J]. Indian Journal of Animal Research, 2021, 55(2).

[22] Clinical Research - Clinical Trials and Studies; CHA University Researchers Describe Findings in Clinical Trials and Studies (Safety and Tolerability of Stromal Vascular Fraction Combined with b-Tricalcium Phosphate in Posterior Lumbar Interbody Fusion: Phase I Clinical Trial) [J]. Biotech Week, 2020.

[23] Dragosloveanu Şerban, Dragosloveanu Christiana D M, Stanca Horia T, Cotor Dragoş C, Andrei Adrian C, Dragosloveanu Călin I, Stoica Cristian I. Tricalcium phosphate and hydroxyapatite treatment for benign cavitary bone lesions: A prospective clinical trial [J]. Experimental and therapeutic medicine, 2020, 20(6).

[24] Fatale Valentina, Pagnoni Stefano, Pagnoni Albino Emidio, Passarelli Pier Carmine, Netti Andrea, Lajolo Carlo, Santacroce Luigi, D’Addona Antonio. Histomorphometric Comparison of New Bone Formed After Maxillary Sinus Lift With Lateral and Crestal Approaches Using Periostal Mesenchymal Stem Cells and Beta-Tricalcium Phosphate: A Controlled Clinical Trial [J]. Journal of Craniofacial Surgery, 2022, 33(5).

[25] Gupta Amit, Arora Karandeep, Aggarwal Priyanka, Kaur Kirandeep, Mohapatra Shreeyam, Pareek Shubhangi. Evaluation of biphasic hydroxapatite and β-tricalcium phosphate as a bone graft material in the treatment of periodontal vertical bony defects—A clinical and digital radiological measurement study [J]. Indian Journal of Dental Research, 2022, 33(2).

[26] Park Hojin, Choi Woo Jong, Jeong Shik Woo. Clinical Application of Three-Dimensional Printing of Polycaprolactone/Beta-Tricalcium Phosphate Implants for Cranial Reconstruction [J]. Journal of Craniofacial Surgery, 2022.

[27] Mendes Bruno Coelho, Pereira Rodrigo dos Santos, Mourão Carlos Fernando de Almeida Barros, Montemezzi Pietro, Santos Anderson Maikon de Souza, Moreno Jéssica Monique Lopes, Okamoto Roberta, HochuliVieira Eduardo. Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial [J]. Materials, 2022, 15(5).

[28] Jeong WooShik, Kim Young Chul, Min Jae Cheong, Park Ho Jin, Lee Eun Ju, Shim Jin Hyung, Choi Jong Woo. Clinical Application of 3D-Printed Patient-Specific Polycaprolactone/Beta Tricalcium Phosphate Scaffold for Complex Zygomatico-Maxillary Defects [J]. Polymers, 2022, 14(4).

[29] Roca Millan Elisabet, JanéSalas Enric, MaríRoig Antonio, JiménezGuerra Álvaro, OrtizGarcía Iván, VelascoOrtega Eugenio, López López José, Monsalve Guil Loreto. The Application of Beta-Tricalcium Phosphate in Implant Dentistry: A Systematic Evaluation of Clinical Studies [J]. Materials, 2022, 15(2).

[30] Asahina Izumi, Kagami Hideaki, Agata Hideki, Honda Masaki J., Sumita Yoshinori, Inoue Minoru, NagamuraInoue Tokiko, Tojo Arinobu. Clinical Outcome and 8-Year Follow-Up of Alveolar Bone Tissue Engineering for Severely Atrophic Alveolar Bone Using Autologous Bone Marrow Stromal Cells with Platelet-Rich Plasma and β-Tricalcium Phosphate Granules [J]. Journal of Clinical Medicine, 2021, 10(22).

How to cite this paper

Zhizhao Hu, Tingrui Ge, Shihan Wu, Yang Hu, Xingxing Ma. Development Status and Application of Tricalcium Phosphate in Oral Clinical Treatment. International Journal of Medicine Frontiers, 2022, 5(1), 32-36.


Copyright © 2022 Damray Co., Ltd. Privacy Policy | Terms and Conditions