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Metformin Use In T2DM With Breast Cancer: A Review

Ya Su

The Affiliated Hospital of Inner Mongolia University for Nationalities, China.

*Corresponding author: Ya Su

Published: September 30,2022 How to cite this paper

Abstract

Recent studies showed that metformin, the most commonly used first-line oral drug for the treatment of type 2 diabetes (T2DM), could prevent and treat various cancers. And many preclinical studies showed that metformin can inhibit the growth of cancer cells in vitro and in vivo. Moreover, multiple evidence suggested that metformin inhibited cancer invasion and metastasis, which could improve the prognosis of cancer patients administrated with metformin. In this summery, we aimed to discuss the possible relationship between breast cancer and metformin use in T2DM from the risk, incidence, response to therapy, prognosis, resistance, and post-therapeutic relapse in cancers. Although some of the controversal studies described, there is no doubt that metformin use in T2DM is benifical for breast cancer.

KEYWORDS: Metformin, T2DM, Breast Cancer, Mammographic Density

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How to cite this paper

Ya Su. Metformin Use In T2DM With Breast Cancer: A Review. International Journal of Medicine Frontiers, 2022, 5(1), 1-9.


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